智能电化学微反应过程课题组

Micro-eChem Group

Journal papers

23. Wireless Electrochemical Reactor for Accelerated Exploratory Study of Electroorganic Synthesis

J. Chen, Y. Mo*

ACS Central Science, 2023, accepted.

DOI: 

22. Accelerated Electrosynthesis Development Enabled by High-Throughput Experimentation

H. Chen, Y. Mo*

Synthesis, 2023, 55, 2817–2832.

DOI: 10.1055/a-2072-2617

21. AROPS: A Framework of Automated Reaction Optimization with Parallelized Scheduling. Journal of Chemical Information and Modeling

Y. Ruan, S. Lin, Y. Mo*

Journal of Chemical Information and Modeling, 2023, accepted.

DOI: 

20.Machine-Learning-Guided Discovery of Electrochemical Reactions

A. F. Zahrt, Y. Mo, K. Y. Nandiwale, R. Shprints, E. Heid, K. F. Jensen*

Journal of the American Chemical Society, 2022, 44, 22599–22610.

DOI: 10.1021/jacs.2c08997

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19. Machine-Learning-Assisted Exploration of Anion-Pillared Metal Organic Frameworks for Gas Separation

J. Hu, J. Cui, B. Gao, L. Yang, Q. Ding, Y. Li, Y. Mo, H. Chen, X. Cui, H. Xing*

Matter, 2022, 5, 3901–3911.

DOI: 10.1016/j.matt.2022.07.029

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18. Autonomous high-throughput screening technology for accelerating drug molecule discovery and synthesis (智能高通量筛选技术加速医药小分子合成)

J. Chen#, X. Zheng#, Y. Ruan#, Y. Mo*

SCIENTIA SINICA Chimica (中国科学: 化学), 2023, 53, 79–94.

DOI: 10.1360/SSC-2022-0101

17. Continuous Stirred-Tank Reactor Cascade Platform for Self-Optimization of Reactions Involving Solids

K. Y. Nandiwale, T Hart, A. F. Zahrt, A. M. K. Nambiar, P. T. Mahesh, Y. Mo, M. J. Nieves-Remacha, M. D. Johnson, P. García-Losada, C. Mateos, J. A. Rincón, K. F. Jensen*

Reaction Chemistry & Engineering, 2022, Accepted.

DOI: 10.1039/D2RE00054G

16. Promotional Synergistic Effect of Fine-tuned Mordenite: Overcoming the Selectivity Limitations of Naphthalene Alkylation with Tert-butyl Alcohol

M. Cai, X. Wang,* Y. Mo, Y. Chen, L. Dai*

Microporous and Mesoporous Materials, 2022, 333, 111725.

DOI: 10.1016/j.micromeso.2022.111725

15. A Scalable Light-diffusing Photochemical Reactor for Continuous Processing of Photoredox Reactions

J. Zhang, Y. Mo*

Chemical Engineering Journal, 2022, 435, 134889.

DOI: 10.1016/j.cej.2022.134889

14. Continuous-Flow Microreactor-Enhanced Clean NAD+ Regeneration for Biosynthesis of 7‑Oxo-lithocholic Acid

H. Li, Z. You, Y. Liu, G. Zheng, H. Gong, Y. Mo, N. Zhu, Y. Bai*, and J. Xu*

ACS Sustainable Chemistry & Engineering, 2022, 10(1), 456–463.

DOI: 10.1021/acssuschemeng.1c06730

13. Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor

R. Duvadie, A. Pomberger, Y. Mo, E. I. Altinoglu, H. Hsieh, K. Y. Nandiwale, V. L. Schultz, K. F. Jensen*, R. I. Robinson*

Organic Process Research & Development, 2021, 25, 10, 2323–2330.

DOI: 10.1021/acs.oprd.1c00251

12. A High-Temperature Continuous Stirred-Tank Reactor Cascade for the Multistep Synthesis of InP/ZnS Quantum Dots

I. Lignos, Y. Mo, L. Carayannopoulos, M. Ginterseder, M. G. Bawendi, K. F. Jensen*

Reaction Chemistry & Engineering, 2021, 6, 459-464.

DOI: 10.1039/D0SC05078D

11. Evaluating and Clustering Retrosynthesis Pathways with Learned Strategy

Y. Mo†, Y. Guan†, P. Verma, J. Guo, M. E. Fortunato, Z. Lu, C. W. Coley, K. F. Jensen*

Chemical Science, 2021, 12, 1469–1478.

DOI: 10.1039/D0SC05078D

10. Towards Efficient Discovery of Green Synthesis Pathways with Monte Carlo Tree Search and Reinforcement Learning

X. Wang, Y. Qian, H. Gao, C. W. Coley, Y. Mo, R. Barzilay, K. F. Jensen*

Chemical Science, 2020, 11(40), 10959-10972.

DOI: 10.1039/D0SC04184J

9. Multifunctional Microfluidic Platform for High-throughput Experimentation of Electroorganic Chemistry

Y. Mo, G. Rughoobur, A. M. K. Nambiar, K. Zhang, K. F. Jensen*

Angewandte Chemie International Edition, 2020, 59 (47), 20890-20894.

DOI: 10.1002/anie.202009819

— Reported by ChemistryViews: Automated Electroorganic Experiments: link.

8. Microfluidic Electrochemistry for Single-electron Transfer Redox-neutral Reactions

Y. Mo†, Z. Lu†, G. Rughoobur, P. Patil, N. Gershenfeld, A. I. Akinwande, S. L. Buchwald*, K. F. Jensen*

Science, 2020, 368, 1352–1357

DOI: 10.1126/science.aba3823

— Highlighted in Science perspective: Closing the Radical Gap in Chemical Synthesis. Science, 2020, 368 (6497), 1312–1313, DOI: 10.1126/science.abc2985.
— Reported by C&EN: Unstable radicals zapped into action in microfluidic electrochemical cell, 2020-06-22: link.
— Reported by Chemistry World: Microfluidic electrochemistry delivers radical coupling breakthrough, 2020-06-19: link.
— Reported by Physics.org (Science X): Method to apply microfluidic electrochemical technologies to single-electron transfer redox-neutral reactions, 2020-06-19: link.
— Reported by X-MOL: 距离产生Science：微流控电化学赋能单电子转移的氧化还原中性反应, 2020-06-25: link.

7. Continuous Flow Suzuki–Miyaura Couplings in Water under Micellar Conditions in a CSTR Cascade Catalyzed by Fe/ppm Pd Nanoparticles

A. B. Wood†, K. Y. Nandiwale†, Y. Mo, B. Jin, A. Pomberger, V. L. Schultz, F. Gallou, K. F. Jensen*, B. H. Lipshutz*

Green Chemistry, 2020, 22 (11), 3441–3444

DOI: 10.1039/D0GC00378F.

6. A Continuous Stirred-tank Reactor (CSTR) Cascade for Handling Solid-containing Photochemical Reactions

A. Pomberger, Y. Mo, K. Y. Nandiwale, V. L. Schultz, R. Duvadie, R. I. Robinson, E. I. Altinoglu, and K. F. Jensen*

Organic Process Research & Development, 2019, 23 (12), 2699–2706

DOI: 10.1021/acs.oprd.9b00378.

5. Adding Crystals to Minimize Clogging in Continuous Flow Synthesis

G. Giri, L. Yang, Y. Mo, and K. F. Jensen*

Crystal Growth & Design, 2019, 19 (1), 98–105

DOI: 10.1021/acs.cgd.8b00999.

4. Scalable Thin-layer Membrane Reactor for Heterogeneous and Homogeneous Catalytic Gas-liquid Reactions

Y. Mo†, J. Imbrogno†, H. Zhang, K. F. Jensen*

Green Chemistry, 2018, 20 (16), 3867–3874

DOI: 10.1039/C8GC01917G.

— Highlighted in Nature Catalysis (DOI: 10.1038/s41929-018-0136-z).
— Featured as one of 2018 Green Chemistry Hot Articles.

3. Continuous NHPI-mediated Electrochemical Aerobic Oxidation of Benzylic C-H Bonds

Y. Mo, K. F. Jensen*

Chemistry–A European Journal, 2018, 24 (40), 10260–10265

DOI: 10.1002/chem.201802588.

2. High-Performance Miniature CSTR for Biphasic C-C Bond-forming Reactions

Y. Mo, H. Lin, K. F. Jensen*

Chemical Engineering Journal, 2018, 335, 936–944

DOI: 10.1016/j.cej.2017.10.114.

1. A Miniature CSTR Cascade for Continuous Flow of Reactions Containing Solids

Y. Mo, K. F. Jensen*

Reaction Chemistry & Engineering, 2016, 1 (5), 501–507

DOI: 10.1039/C6RE00132G.

— Top 10 most-read articles from Q1 2017 to Q1 2018.

Patents

  1. Z. Lin, Y. Mo, and R. Li. Method to Identify the Waste Edible Oil Based on Hydroxyl Value. China Patent CN201210320081.4.

Book chapters

  1. C. W. Coley, J. Imbrogno, Y. Mo, D. A. Thomas, K. F. Jensen, “Flow Chemistry System Design and Automation”, in Science of Synthesis: Flow Chemistry in Organic Synthesis, T.F. Jamison, and G. Koch, Thieme, 3–50, 2018.

Conferences & Invited talks

  1. 莫一鸣，（口头报告）微流控电化学合成：交叉偶联中活性自由基的精准控制，2020中国化工学会科技创新大会—— 分子化学工程论坛分会场，2020年9月16日.
  2. 莫一鸣，（特邀报告）流动电化学在有机合成领域的应用，清华大学化学工程联合国家重点实验室学术论坛第三十四期，2020年6月28日.
  3. Y. Mo, G. Rughoobur, Z. Lu, A. M. K. Nambiar, K. F. Jensen. Automated Nanomole-Scale Platform for Rapid Screening and Optimization of Electroorganic Synthesis. 2019 AIChE Annual Meeting. Oral presentation.
  4. Y. Mo, J. Imbrogno, H. Zhang, and K.F. Jensen. Scalable Thin-Layer Membrane Reactor for Heterogeneous and Homogeneous Catalytic Gas–Liquid Reactions. 2019 AIChE Annual Meeting. Oral presentation.
  5. Y. Mo, J. Imbrogno, H. Zhang, and K.F. Jensen. Towards Green Organic Synthesis Process: Use of Gaseous Reagents and Electrons in Continuous Flow. 2018 AIChE Annual Meeting. Oral presentation.
  6. Y. Mo and K.F. Jensen. A Miniature CSTR Platform for Continuous Processing of Multiphase Systems. 2017 AIChE Annual Meeting. Oral presentation.